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Prescription esomeprazole is used to treat the symptoms of gastroesophageal reflux disease (GERD), a condition in which stomach acid backs up into the esophagus, causing reflux and possible injury to the esophagus (the tube between the throat and stomach) in adults and children 1 year and older. Prescription esomeprazole is used to treat damage caused by GERD in adults and children 1 month and older. Prescription esomeprazole is used to allow the esophagus to heal and to prevent further damage to the esophagus in adults with GERD. Prescription esomeprazole is also used to decrease the chance that adult patients taking nonsteroidal anti-inflammatory drugs (NSAIDs) will develop ulcers (sores in the lining of the stomach or intestine). It is also used with other medications to treat and prevent the recurrence of stomach ulcers caused by a certain type of bacteria (H. pylori) in adults. Prescription esomeprazole is also used to treat conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome in adults. Over-the-counter esomeprazole is used to treat frequent heartburn (burning stomach that occurs at least 2 or more days a week) in adults. Esomeprazole belongs to a class of medications called proton pump inhibitors. It works by decreasing the amount of acid produced in the stomach.

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