Sulfonamides

Treatment of urinary tract infections such as pyelonephritis, cystitis, urethritis, acute and chronic prostatitis, asymptomatic bacteriuria, and prophylaxis of recurrent infections. Gastrointestinal infections such as enteritis, gastroenteritis, traveler's diarrhea, shigellosis, salmonellosis, and typhoid fever. LABORATORIOS QUÍMICA SON'S, S.A. de C.V.

Mechanism of Action Sulfamethoxazole and Trimethoprim Sulfamethoxazole competitively inhibits the utilization of para-aminobenzoic acid (PABA) in the synthesis of dihydrofolate produced in bacterial cells, producing bacteriostasis. Trimethoprim reversibly inhibits bacterial dihydrofolate reductase (DHFR), an enzyme active in the folate metabolic pathway, which converts dihydrofolate to tetrahydrofolate. Depending on the conditions, the effect could be bactericidal. Thus, trimethoprim and sulfamethoxazole block two consecutive steps in purine biosynthesis and, therefore, nucleic acids essential for many bacteria. This action produces a marked enhancement of the in vitro activity of the two agents.

Silver sulfadiazine, a sulfonamide, is used to prevent and treat infections in second- and third-degree burns. It kills a wide variety of bacteria. MD Liferpal Laboratory

Acute otitis media; acute exacerbations of chronic bronchitis in patients without risk factors; uncomplicated acute urinary tract infections (cystitis, pyelonephritis); infectious diarrhea; treatment of toxoplasmosis; granuloma inguinale (donovanosis); brucellosis. Lab Maver